D-vitamiini, äärimmäisen tärkeä vitamiini

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Kritiikkiä D-vitamiinin ylikulutuksesta.

http://www.uusisuomi.fi/kotimaa/109553-%E2%80%9Dd-vitamiinin-supersyonti-on-myrkyllista%E2%80%9D

Paula Hakala on siis eri mieltä kuin maailman johtavat D-vitamiiniasiantuntijat:

<a href="http://www.youtube.com/v/emjCzaHtSrg" target="_blank" class="new_win">http://www.youtube.com/v/emjCzaHtSrg</a>


Paula Hakalan höpöpuheet ownattu Suomen parhaalla ravintofoorumilla: (Itse tosin olen hieman eri mieltä optimaalisesta saannista. Pyrin vähintään 125 nmol/l -tasoon.)

http://foodit.fi/ruokavaliot/vitamiini-d-vitamiini/msg9672/#msg9672


Paula Hakalan tiedot on täysin vanhentuneita.

Alle 10000IU/250µg -annoksilla ei ole mitään pelkoa yliannoksesta aikuisilla ihmisillä. Aurinkoa ottamalla saa helposti tuon 250µg.

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Heaneyn mukaan 80 nmol/l on ehdoton minimi kenelle tahansa, ja 120nmol/l on todennäköisesti lähempänä optimia. 150 nmol/l on luonnollinen arvo, joka alkukantaisella ihmisellä arvellaan olleen.

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Researchers at the University of California, San Diego School of Medicine and Creighton University School of Medicine in Omaha have reported that markedly higher intake of vitamin D is needed to reach blood levels that can prevent or markedly cut the incidence of breast cancer and several other major diseases than had been originally thought. The findings are published February 21 in the journal Anticancer Research

While these levels are higher than traditional intakes, they are largely in a range deemed safe for daily use in a December 2010 report from the National Academy of Sciences Institute of Medicine.

“We found that daily intakes of vitamin D by adults in the range of 4000-8000 IU are needed to maintain blood levels of vitamin D metabolites in the range needed to reduce by about half the risk of several diseases – breast cancer, colon cancer, multiple sclerosis, and type 1 diabetes,” said Cedric Garland, DrPH, professor of family and preventive medicine at UC San Diego Moores Cancer Center. “I was surprised to find that the intakes required to maintain vitamin D status for disease prevention were so high – much higher than the minimal intake of vitamin D of 400 IU/day that was needed to defeat rickets in the 20th century.”

“I was not surprised by this” said Robert P. Heaney, MD, of Creighton University, a distinguished biomedical scientist who has studied vitamin D need for several decades. “This result was what our dose-response studies predicted, but it took a study such as this, of people leading their everyday lives, to confirm it.”

The study reports on a survey of several thousand volunteers who were taking vitamin D supplements in the dosage range from 1000 to 10,000 IU/day. Blood studies were conducted to determine the level of 25-vitamin D – the form in which almost all vitamin D circulates in the blood.

“Most scientists who are actively working with vitamin D now believe that 40 to 60 ng/ml is the appropriate target concentration of 25-vitamin D in the blood for preventing the major vitamin D-deficiency related diseases, and have joined in a letter on this topic,” said Garland. “Unfortunately, according a recent National Health and Nutrition Examination Survey, only 10 percent of the US population has levels in this range, mainly people who work outdoors.”

Interest in larger doses was spurred in December of last year, when a National Academy of Sciences Institute of Medicine committee identified 4000 IU/day of vitamin D as safe for every day use by adults and children nine years and older, with intakes in the range of 1000-3000 IU/day for infants and children through age eight years old.

While the IOM committee states that 4000 IU/day is a safe dosage, the recommended minimum daily intake is only 600 IU/day.

“Now that the results of this study are in, it will become common for almost every adult to take 4000 IU/day,” Garland said. “This is comfortably under the 10,000 IU/day that the IOM Committee Report considers as the lower limit of risk, and the benefits are substantial.” He added that people who may have contraindications should discuss their vitamin D needs with their family doctor.

“Now is the time for virtually everyone to take more vitamin D to help prevent some major types of cancer, several other serious illnesses, and fractures,” said Heaney.

Lähde: Kalifornian yliopiston lehdistötiedote

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http://onlinelibrary.wiley.com/doi/10.1002/jbmr.328/full
The IOM recommendations for vitamin D fail in a major way on logic, on science, and on effective public health guidance. Moreover, by failing to use a physiological referent, the IOM approach constitutes precisely the wrong model for development of nutritional policy. © 2011 American Society for Bone and Mineral Research.

http://onlinelibrary.wiley.com/doi/10.1002/jbmr.328/pdf

The IOM report (and its presentation to the media) stressed
that its recommendations for vitamin D were based primarily
on the intake (and serum 25-hydroxyvitamin D concentration)
needed to ensure skeletal health and that, in the panel’s
judgment, there was insufficient evidence to make any
recommendations with respect to nonskeletal benefits, if any.
Second, the report concluded that a serum level for 25-
hydroxyvitamin D [25(OH)D] of 20 ng/mL was sufficient to ensure
bone health. And third, the panel concluded that since the bulk
of the American public had 25(OH)D values that were above
20 ng/mL, most individuals were getting all the vitamin D they
needed and had no reason for further supplementation. These
conclusions fail on three grounds: logic, science, and guidance.

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Hieman konservatiivisempi arvio optimaalisesta vitamiinitasosta.

http://www.ncbi.nlm.nih.gov/pubmed/20720256

CONCLUSIONS: Both high and low concentrations of plasma 25(OH)D are associated with elevated risks of overall and cancer mortality. Low concentrations are associated with cardiovascular mortality.


An approximately 50% higher total mortality rate was observed among men in the lowest 10% (<46 nmol/L) and the highest 5% (>98 nmol/L) of plasma 25(OH)D concentrations compared with intermediate concentrations. Cancer mortality was also higher at low plasma concentrations (multivariable-adjusted HR: 2.20; 95% CI: 1.44, 3.38) and at high concentrations (HR: 2.64; 95% CI: 1.46, 4.78). For cardiovascular death, only low (HR: 1.89; 95% CI: 1.21, 2.96) but not high (HR: 1.33; 95% CI: 0.69, 2.54) concentrations indicated higher risk.

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http://www.vitamindcouncil.org/health/deficiency/am-i-vitamin-d-deficient.shtml
Am I Vitamin D Deficient?

 Good Question! There is no way to know for certain until you get a 25-hydroxyvitamin D test, also called a 25(OH)D. Levels should be above 50 ng/ml (125 nmol/L) year-round, in both children and adults. Thanks to Bruce Hollis, Robert Heaney, Neil Binkley, and others, we now know the minimal acceptable level. It is 50 ng/ml (125 nmol/L). In a recent study, Heaney, et al expanded on Bruce Hollis's seminal work by analyzing five studies in which both the parent compound (cholecalciferol) and 25(OH)D levels were measured. They found that the body does not reliably begin storing cholecalciferol in fat and muscle tissue until 25(OH)D levels get above 50 ng/ml (125 nmol/L). The average person starts to store cholecalciferol at 40 ng/ml (100 nmol/L), but at 50 ng/ml (125 nmol/L) virtually everyone begins to store it for future use. That is, at levels below 50 ng/ml (125 nmol/L), the body uses up vitamin D as fast as you can make it, or take it, indicating chronic substrate starvation—not a good thing. 25(OH)D levels should be between 50–80 ng/ml (125–200 nmol/L), year-round

[Julkkikset Team]

http://www.newyoumag.com/magazine/spring-2011/diagnosis-vitamin-d/

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Vallan kummallista on se, että kalsiumia käsketään syömään, ja liikaa D-vitamiinia varomaan. Asia on todellisuudessa täysin päinvastoin.

http://www.tohtori.fi/?page=4031888&id=4677104